AUTHOR=Yan Nao , Zhang Jun-Jian 

TITLE=The Emerging Roles of Ferroptosis in Vascular Cognitive Impairment

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 13 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.00811

DOI=10.3389/fnins.2019.00811

ISSN=1662-453X

ABSTRACT=Vascular cognitive impairment (VCI) is a clinical syndrome that encompasses all forms of cognitive deficits caused by cerebrovascular disease, from mild cognitive impairment (MCI) to dementia. Vascular dementia (VD),the second most common type of dementia after Alzheimer's disease (AD), accounts for approximately 20% of dementia patients.Ferroptosis is a recently defined iron-dependent form of cell death, which is distinct from apoptosis, necrosis, autophagy and other forms of cell death. Emerging evidence suggested that ferroptosis has significant implications in neurological diseases such as stroke, traumatic brain injury and AD.And  ferroptosis inhibition have obvious neuroprotective effect and ameliorate cognitive impairment in various animals models . Here,we summarizes the underlying mechanisms of ferroptosis, and reviews the close relationship between ferroptosis and VCI.