AUTHOR=Caravaca April S. , Gallina Alessandro L. , Tarnawski Laura , Tracey Kevin J. , Pavlov Valentin A. , Levine Yaakov A. , Olofsson Peder S. 

TITLE=An Effective Method for Acute Vagus Nerve Stimulation in Experimental Inflammation

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 13 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.00877

DOI=10.3389/fnins.2019.00877

ISSN=1662-453X

ABSTRACT=Neural reflexes regulate inflammation and electrical activation of the vagus nerve reduces inflammation in several models of inflammatory disease. These discoveries have generated an increasing interest in targeted neurostimulation as specific treatment for chronic inflammatory diseases. Data from the first clinical trials that use vagus nerve stimulation in treatment of rheumatoid arthritis and Chron´s disease suggest that there is a therapeutic potential of electrical vagus nerve stimulation in diseases characterized by excessive inflammation. Accordingly, there is an interest to further explore the molecular mechanisms and therapeutic potential of electrical vagus nerve stimulation experimentally in a range of experimental settings and available genetic mouse models of disease. Here, we describe a simple method for consistent electrical vagus nerve stimulation in the mouse.