AUTHOR=Hardy John 

TITLE=Failures in Protein Clearance Partly Underlie Late Onset Neurodegenerative Diseases and Link Pathology to Genetic Risk

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 13 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.01304

DOI=10.3389/fnins.2019.01304

ISSN=1662-453X

ABSTRACT=As we identify the loci involved in late onset neurodegenerative disease we are finding that the majority of them are involved in damage response processes.  In this short review I propose that it is a largely failure in these damage response processes which underly late onset disease and that the resultant pathology is a marker of the type of damage response which has failed: microglial clearance of damaged neuronal membranes in Alzheimer’s disease, ubiquitin proteasome clearance in the tauopathies, and lysosomal clearance in Parkinson’s disease