AUTHOR=Hu Wei , Pan Donghui , Wang Yalin , Bao Weiqi , Zuo Chuantao , Guan Yihui , Hua Fengchun , Yang Min , Zhao Jun 

TITLE=PET Imaging for Dynamically Monitoring Neuroinflammation in APP/PS1 Mouse Model Using [18F]DPA714

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 14 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2020.00810

DOI=10.3389/fnins.2020.00810

ISSN=1662-453X

ABSTRACT=Background: In the pathogenesis of Alzheimer's diseases, microglia plays an increasing important role. Especially, molecular imaging of neuroinflammatory targeting microglia activation and high expression of 18-kDa translocator protein is a hot research focus in recent years. Dynamically monitor neuroinflammation is crucial for discovering the best time point of antiinflammatory therapy. Motivated by this, PET imaging in a APP/PS1 mouse model of Alzheimer's Diseases using 18F-labeled DPA-714 to monitor microglia activation and neuroinflammation are performed in this paper.