AUTHOR=Wang Yangong , Xu Yiran , Fan Yangyi , Bi Dan , Song Juan , Xia Lei , Shang Qing , Gao Chao , Zhang Xiaoli , Zhu Dengna , Qiao Yimeng , Su Yu , Wang Xiaoyang , Zhu Changlian , Xing Qinghe 

TITLE=The Association Study of IL-23R Polymorphisms With Cerebral Palsy in Chinese Population

JOURNAL=Frontiers in Neuroscience

VOLUME=14

YEAR=2020

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2020.590098

DOI=10.3389/fnins.2020.590098

ISSN=1662-453X

ABSTRACT=<p><bold>Background:</bold> Cerebral palsy (CP) is a syndrome of non-progressive motor dysfunction caused by early brain development injury. Recent evidence has shown that immunological abnormalities are associated with an increased risk of CP.</p><p><bold>Methods:</bold> We recruited 782 children with CP as the case group and 770 healthy children as the control group. The association between <italic>IL-23R</italic> single nucleotide polymorphisms (SNPs; namely, rs10889657, rs6682925, rs1884444, rs17375018, rs1004819, rs11805303, and rs10889677) and CP was studied by using a case–control method and SHEsis online software. Subgroup analysis based on complications and clinical subtypes was also carried out.</p><p><bold>Results:</bold> There were differences in the allele and genotype frequencies between CP cases and controls at the rs11805303 and rs10889677 SNPs (<italic>P</italic>allele = 0.014 and 0.048, respectively; <italic>P</italic>genotype = 0.023 and 0.008, respectively), and the difference in genotype frequency of rs10889677 remained significant after Bonferroni correction (<italic>P</italic>genotype = 0.048). Subgroup analysis revealed a more significant association of rs10889677 with CP accompanied by global developmental delay (<italic>P</italic>genotype = 0.024 after correction) and neonatal encephalopathy (<italic>P</italic>genotype = 0.024 after correction).</p><p><bold>Conclusion:</bold> The present results showed a significant association between <italic>IL-23R</italic> and CP, suggesting that <italic>IL-23R</italic> may play a potential role in CP pathogenesis.</p>