AUTHOR=Zhang Yanyan , Li Jie , Zhang Xiao , Song Dongdong , Tian Tian 

TITLE=Advances of Mechanisms-Related Metabolomics in Parkinson’s Disease

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 15 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.614251

DOI=10.3389/fnins.2021.614251

ISSN=1662-453X

ABSTRACT=Parkinson’s disease (PD) is a multifactorial disorder characterized by progressively debilitating dopaminergic neurodegeneration in the substantia nigra and the striatum, along with various metabolic dysregulations and molecular abnormalities. Metabolomics is an emerging study and has been demonstrated to play important roles in describing the complex human diseases by integrating endogenous and exogenous sources of alterations. Recently, an increasing number of researches have shown that the metabolomics profiling hold great promise to provide unique insights into the molecular pathogenesis and be helpful of identifing candidate biomarkers for clinical detection and therapies of PD. In this review, we briefly summarize recent findings and analyse the application of molecular metabolomics in familial and sporadic PD from different domains, including genetic mutations, mitochondrial dysfunction and dysbacteriosis, with a brief overview of diagnostic biomarkers to represent the functional stage and improve therapeutic strategies to postpone or hinder the disease progression.