AUTHOR=Stern Tehila , Crutcher Emeline H. , McCarthy John M. , Ali May A. , Issachar Gil , Geva Amir B. , Peremen Ziv , Schaaf Christian P. 

TITLE=Brain Network Analysis of EEG Recordings Can Be Used to Assess Cognitive Function in Teenagers With 15q13.3 Microdeletion Syndrome

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 15 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.622329

DOI=10.3389/fnins.2021.622329

ISSN=1662-453X

ABSTRACT=15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders, including intellectual disability and autism. We assessed the ability of the EEG analysis algorithm Brain Network Analysis (BNA) to measure cognitive function in 15q13.3 deletion patients and to differentiate between patient and control groups. EEG data were collected from ten individuals with 15q13.3 microdeletion syndrome (14–18 years of age), as well as thirty age-matched healthy controls, as the subjects
responded to Auditory Oddball (AOB) and Go/NoGo cognitive tasks. It was determined that BNA can be used to evaluate cognitive function in 15q13.3 microdeletion patients. This analysis also significantly differentiates between patient and control groups using 5 scores, all of which are BNA-Based produced from ERP peaks related to late cortical components that represent higher cognitive functions of attention allocation and response inhibition (P < 0.05).