AUTHOR=Ponirakis Georgios , Elsotouhy Ahmed , Al Hamad Hanadi , Vattoth Surjith , Petropoulos Ioannis N. , Khan Adnan , Gad Hoda , Al-Khayat Fatima , Chandran Mani , Ramadan Marwan , Elorrabi Marwa , Gadelseed Masharig , Tosino Rhia , Gawhale Priya V. , Alobaidi Maryam , Khan Shafi , Manikoth Pravija , Abdelrahim Yasmin H. M. , Thodi Noushad , Almuhannadi Hamad , Al-Mohannadi Salma , AlMarri Fatema , Qazi Murtaza , Own Ahmed , Mahfoud Ziyad R. , Shuaib Ashfaq , Malik Rayaz A.
TITLE=Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia
JOURNAL=Frontiers in Neuroscience
VOLUME=15
YEAR=2021
URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.690896
DOI=10.3389/fnins.2021.690896
ISSN=1662-453X
ABSTRACT=IntroductionThis study assessed the association of cerebral ischemia with neurodegeneration in mild cognitive impairment (MCI) and dementia.
MethodsSubjects with MCI, dementia and controls underwent assessment of cognitive function, severity of brain ischemia, MRI brain volumetry and corneal confocal microscopy.
ResultsOf 63 subjects with MCI (n = 44) and dementia (n = 19), 11 had no ischemia, 32 had subcortical ischemia and 20 had both subcortical and cortical ischemia. Brain volume and corneal nerve measures were comparable between subjects with subcortical ischemia and no ischemia. However, subjects with subcortical and cortical ischemia had a lower hippocampal volume (P < 0.01), corneal nerve fiber length (P < 0.05) and larger ventricular volume (P < 0.05) compared to those with subcortical ischemia and lower corneal nerve fiber density (P < 0.05) compared to those without ischemia.
DiscussionCerebral ischemia was associated with cognitive impairment, brain atrophy and corneal nerve loss in MCI and dementia.