AUTHOR=Cifre Ignacio , Miller Flores Maria T. , Penalba Lucia , Ochab Jeremi K. , Chialvo Dante R. 

TITLE=Revisiting Nonlinear Functional Brain Co-activations: Directed, Dynamic, and Delayed

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 15 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.700171

DOI=10.3389/fnins.2021.700171

ISSN=1662-453X

ABSTRACT=The center stage of neuro-imaging is currently occupied by studies of functional correlations between brain regions. These correlations define the brain functional networks, which are the most frequently used framework to represent and interpret a variety of experimental findings. In previous work we first demonstrated  that the relatively stronger BOLD activations contain most of the information relevant to understand functional connectivity, and subsequent work  confirmed that a large compression of the original signals can be obtained without significant loss of information. In this work, we revisit  the correlation properties of these epochs to define a measure of nonlinear dynamic directed functional connectivity nldFC across regions of interest.  
We show that the proposed metric provides at once, without extensive numerical complications, directed information of the functional correlations, as well as a measure of temporal lags across regions, overall offering a different and complementary perspective in the analysis of brain co-activation patterns. 
In this paper, we provide for further details for the computations of these measures and for a proof of concept based on replicating existing results from an Autistic Syndrome database, and discuss the main features and advantages of the proposed strategy for the study of brain functional correlations.