AUTHOR=Hu Mandong , Zhong Yi , Xie Shuxuan , Lv Haibin , Lv Zhihan TITLE=Fuzzy System Based Medical Image Processing for Brain Disease Prediction JOURNAL=Frontiers in Neuroscience VOLUME=Volume 15 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.714318 DOI=10.3389/fnins.2021.714318 ISSN=1662-453X ABSTRACT=The present work aims to explore the performance of fuzzy system-based medical image processing for brain disease prediction. The imaging mechanism of NMR (Nuclear Magnetic Resonance) and the complexity of human brain tissues cause the brain MRI (Magnetic Resonance Imaging) images to present varying degrees of noise, weak boundaries, and artifacts. Hence, improvements are made over the fuzzy clustering algorithm. While ensuring the model safety performance, a brain image processing and brain disease diagnosis prediction model is designed based on improved fuzzy clustering and HPU-Net (Hybrid Pyramid U-Net Model for Brain Tumor Segmentation). Brain MRI images collected from the Department of Brain Oncology, XX Hospital, are employed in simulation experiments to validate the performance of the proposed algorithm. Moreover, CNN (Convolutional Neural Network), RNN (Recurrent Neural Network), FCM (Fuzzy C-Means), LDCFCM (Local Density Clustering Fuzzy C-Means), and AFCM (Adaptive Fuzzy C-Means) are included in simulation experiments for performance comparison. Results demonstrated that the proposed algorithm has more nodes, lower energy consumption, and more stable changes than other models under the same conditions. Regarding the overall network performance, the proposed algorithm can complete the data transmission tasks the fastest, basically maintaining at about 4.5 seconds on average, which performs remarkably better than other models. A further prediction performance analysis reveals that the proposed algorithm provides the highest prediction accuracy for the Whole Tumor under the DSC coefficient, reaching 0.936. Besides, its Jaccard coefficient is 0.845, proving its superior segmentation accuracy over other models. To sum up, the proposed algorithm can provide higher accuracy while ensuring energy consumption, a more apparent denoising effect, and the best segmentation and recognition effect than other models, which can provide an experimental basis for the feature recognition and predictive diagnosis of brain images.