AUTHOR=Wang Bin , Zeng Hongtao , Liu Jingliu , Sun Miao 

TITLE=Effects of Prenatal Hypoxia on Nervous System Development and Related Diseases

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 15 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.755554

DOI=10.3389/fnins.2021.755554

ISSN=1662-453X

ABSTRACT=The fetal origin adult diseases hypothesis was proposed by David Barker in the UK in the late 1980s, which mainly believed that adult chronic diseases originated from various adverse stimuli in early fetal development. Fetal origin adult diseases are associated with a wide range of adult chronic diseases, such as cardiovascular disease, type 2 diabetes, cancer, and neurological disorders such as depression, anxiety, and autism. Intrauterine hypoxia is one of the most common complications of obstetrics. Numerous studies have confirmed that intrauterine fetal hypoxia leads to alterations in brain structure and function and is strongly associated with neurological disorders such as cognitive impairment and anxiety. However, the mechanism that fetal hypoxia causes this adult chronic disease remains unclear. Based on the existing literature, we have summarized the causes of prenatal hypoxia, the effects of prenatal hypoxia on brain development and behavioral phenotype, the responses of different species and different periods to prenatal hypoxia, and the possible molecular mechanisms.