AUTHOR=Sun Ying , Zou Shengyu , He Zuhong , Chen Xiong 

TITLE=The role of autophagy and ferroptosis in sensorineural hearing loss

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 16 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.1068611

DOI=10.3389/fnins.2022.1068611

ISSN=1662-453X

ABSTRACT=Hearing loss has become a common sensory defect in humans. Because of the limited regeneration ability of mammalian cochlear hair cells (HCs), hair cell damage (caused by ototoxic drugs, aging, and noise) is the main risk factor of hearing loss. However, how HCs can be protected from risk factors remains to be investigated. Autophagy is a process by which damaged cytoplasmic components are sequestered into lysosomes for degradation. Ferroptosis is a novel form of nonapoptotic regulated cell death, involving intracellular iron overloading and iron-dependent lipid peroxide accumulation. Recent studies have confirmed that autophagy is associated with ferroptosis, and their crosstalk may be the potential therapeutic target for hearing loss. In this review, we overview the mechanisms of ferroptosis and autophagy, as well as their relationship to HC damage, which may provide insight into a new future in the protection of HCs.