AUTHOR=Tiruvadi Vineet , Choi Ki Sueng , Gross Robert E. , Butera Robert , Jirsa Viktor , Mayberg Helen 

TITLE=Dynamic Oscillations Evoked by Subcallosal Cingulate Deep Brain Stimulation

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 16 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.768355

DOI=10.3389/fnins.2022.768355

ISSN=1662-453X

ABSTRACT=Deep brain stimulation (DBS) of subcallosal cingulate white matter (SCCwm) alleviates
symptoms of depression, but its mechanistic effects on brain dynamics remain unclear. In
this study we used a novel combination of intracranial (LFP) and non-invasive (EEG) neural
recordings during SCCwm-DBS, and observed a novel dynamic oscillation (DOs) evoked by
DBS within the SCC. When present, LFP-DOs were consistently evoked by DBS within the
SCC, supporting a neural source, and exhibited dynamics evolving over minutes. LFP-DOs were
associated with engagement of distinct white matter tracts, and we observed preliminary evidence
that DOs are evoked in EEG recordings downstream of stimulated SCCwm under therapeutic
conditions. These results provide an signal for further study of SCCwm-DBS effects and potential
applications in connectomic and steerable DBS.