AUTHOR=Mizuguchi Masashi , Shibata Akiko , Kasai Mariko , Hoshino Ai 

TITLE=Genetic and environmental risk factors of acute infection-triggered encephalopathy

JOURNAL=Frontiers in Neuroscience

VOLUME=17

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1119708

DOI=10.3389/fnins.2023.1119708

ISSN=1662-453X

ABSTRACT=<p>Acute encephalopathy is a constellation of syndromes in which immune response, metabolism and neuronal excitation are affected in a variable fashion. Most of the syndromes are complex disorders, caused or aggravated by multiple, genetic and environmental risk factors. Environmental factors include pathogenic microorganisms of the antecedent infection such as influenza virus, human herpesvirus-6 and enterohemorrhagic <italic>Escherichia coli</italic>, and drugs such as non-steroidal anti-inflammatory drugs, valproate and theophylline. Genetic factors include mutations such as rare variants of the <italic>SCN1A</italic> and <italic>RANBP2</italic> genes, and polymorphisms such as thermolabile <italic>CPT2</italic> variants and <italic>HLA</italic> genotypes. By altering immune response, metabolism or neuronal excitation, these factors complicate the pathologic process. On the other hand, some of them could provide promising targets to prevent or treat acute encephalopathy.</p>