AUTHOR=Li Dong-Jin , Huang Bing-Lin , Peng Yuan , Liang Ling-Yan , Liu Hui 

TITLE=Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 17 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1131247

DOI=10.3389/fnins.2023.1131247

ISSN=1662-453X

ABSTRACT=Abstract
Purpose: Glaucoma is the main blindness-causing disease in the world. Previous neuroimaging studies demonstrated that glaucoma not only causes loss of optic ganglion cells, but also leads to abnormal function of the optic nerve pathway and visual cortex. However, previous studies also reported that glaucoma patients have dysfunction in the visual cortex in a static state. Whether or not the primary angle-closure glaucoma (PACG) patients were accompanied by dynamic functional connectivity (FC) changes in the primary visual cortex (V1) remains unknown. 
Methods: A total of 34 PACG patients (23 males and 11 females) and 34 well-matched healthy controls (HCs) were enrolled in the study. The dynamic functional connectivity (dFC) with the sliding window method was applied to investigate the dynamic functional connectivity changes in the V1.
Results: Compared with HCs, PACG patients showed increased dFC values between left V1 and bilateral calcarine (CAL). Meanwhile, PACG patients showed increased dFC values between right V1 and bilateral CAL.  
Conclusion: Our study demonstrated that PACG patients showed increased dFC within the visual network, which might indicate the increased variability FC in the V1 in PACG patients.