AUTHOR=Wang Huihui , Wen Hongwei , Li Jing , Chen Qian , Li Shanshan , Wang Zhenchang 

TITLE=Disrupted topological organization of white matter structural networks in high myopia patients revealed by diffusion kurtosis imaging and tractography

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 17 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1158928

DOI=10.3389/fnins.2023.1158928

ISSN=1662-453X

ABSTRACT=High myopia (HM) is a public health issue which can lead to severe visual impairment. Previous studies have exhibited widespread white matter (WM) integrity damages in HM patients. However, how these WM damages are topologically related, and the network-level structural disruptions underlying HM has not been fully defined. We aimed to assess the alterations of brain WM structural networks in HM patients using diffusion kurtosis imaging (DKI) and tractography in the present study. Individual whole-brain and ROI-level WM networks were constructed using DKI tractography in 30 HM patients and 33 healthy controls. Graph theory analysis was then applied to explore the altered global and regional network topological properties. Pearson correlations between regional properties and disease duration in HM group were also assessed. For global topology, although both groups showed an small-world network organization, HM patients exhibited significant decreased local efficiency and clustering coefficient compared with controls. For regional topology, HM patients and controls showed highly similar hub distributions, except for three additional hub regions in HM patients including left insula, anterior cingulate and paracingulate gyri (ACG) and median cingulate and paracingulate gyri (DCG). In addition, HM patients showed significantly altered nodal betweenness centrality (BC) mainly in the bilateral inferior occipital gyrus (IOG), left superior occipital gyrus (SOG), caudate nucleus, rolandic operculum and right putamen, pallidum, gyrus rectus compared with controls. Intriguingly, the nodal BC of left IOG was negatively correlated with disease duration in HM patients. Our findings suggest that HM exhibited alterations in WM structural network of the brain, mainly manifested local specialization decreased. This study may advance the current understanding of the pathophysiological mechanisms underlying HM.