AUTHOR=Liu Yi-Rong , Liang Chao-Feng , Zhao Han-Qiao , Ou Yun-Mou , Wu Jian 

TITLE=A polarization image enhancement method for glioma

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 17 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1163701

DOI=10.3389/fnins.2023.1163701

ISSN=1662-453X

ABSTRACT=Polarization imaging technique (PIT) based on backward scattering 3×3 Mueller matrix polarization imaging experimental setup is able to study the optical information and microstructure of glioma and non-glioblastoma tissues from clinical treatment. However, the image contrast of Mueller Matrix Elements (MME) is far from sufficient to provide supplemental information in the clinic, especially in off-diagonal MME. The aim of this work is to propose an innovative method to improve the contrast and quality of PIT images of glioma and non-glioma tissues. The work first confirms the robustness of the method by evaluating the enhanced images and assessment coefficients on ex-vivo unstained glioma and non-glioma sample bulks, then the optimally enhancement results are tested and presented based on the multi-sample tests. The proposed method can further be used to identify glioma and residues in the intraoperative environment with PIT.