AUTHOR=Zhang Zhiyun , Wang Shengnan , Ren Fei , Yang Laiyu , Xie Haoqun , Pan Lin , Li Yifan , Yu Bingcheng , Yang Yifan , Su Haoyi , Chen Youqi , Zhang Chuyi , Chen Hongyu , Yang Wenzhuo , An Nan , Bai Yang 

TITLE=Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 17 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1186312

DOI=10.3389/fnins.2023.1186312

ISSN=1662-453X

ABSTRACT=Background: Meningiomas are one of the most common intracranial tumors, and the current understanding of meningioma pathology is still incomplete. Inflammatory factors play an important role in the pathophysiology of meningioma, but the causal relationship between inflammatory factors and meningioma is still unclear. 
Method: Mendelian randomization (MR) is an effective statistical method for reducing bias based on whole genome sequencing data. It’s a simple but powerful framework, uses genetics to study aspects of human biology. Modern methods of MR make the process more robust by exploiting the many genetic variants that may exist for a given hypothesis. In this paper, MR is applied to understand the causal relationship between exposure and disease outcome.
Results: Our results showed that higher tumor necrosis factor-beta (TNF-β) levels are linked to a higher incidence of meningiomas (OR=1.351, 95%CI=1.015-1.797, p=0.039). Furthermore, meningiomas predicted by genes have no effect on the expression of systemic inflammatory regulators. 
Conclusion: These findings suggest that TNF-β play a crucial part in the growth of meningiomas. Further research is needed to see if the biomarker can be utilized to prevent or treat meningiomas.