AUTHOR=Zhang Qingping , Jing Wei , Wu Shiping , Zhu Mengzheng , Jiang Jingrui , Liu Xiang , Yu Dian , Cheng Long , Feng Bin , Wen Jianbin , Xiong Feng , Lu Youming , Du Huiyun 

TITLE=Development of a synchronous recording and photo-stimulating electrode in multiple brain neurons

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 17 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1195095

DOI=10.3389/fnins.2023.1195095

ISSN=1662-453X

ABSTRACT=Neurophysiological activity and its regulation have been widely used in brain network and neural circuit studies. Electrophysiology recording and optogenetic stimulation can be performed via opto-electrodes, which facilitate the decoding of neural codes. However, chronic multi-regional recording/stimulation is still a challenging task for achieving high implantation accuracy and electrode weight control. Here, we design a novel electrode based on the custom printed circuits boards and matching molds and report the results of the opto-electrode placement accuracy and the high-quality electrophysiological recordings from mouse default mode network (DMN) and hence, provide a novel opto-electrode that reveals synchronous recording and stimulation in multiple brain neurons and facilitates future neural circuit and network research.