AUTHOR=Overk Cassia , Fiorini Emma , Babolin Chiara , Vukicevic Marija , Morici Catherine , Madani Rime , Eligert Valerie , Kosco-Vilbois Marie , Roberts Amanda , Becker Ann , Pfeifer Andrea , Mobley William C. 

TITLE=Modeling Alzheimer’s disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 17 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1202208

DOI=10.3389/fnins.2023.1202208

ISSN=1662-453X

ABSTRACT=People with DS are highly predisposed to Alzheimer's disease (AD) and demonstrate very similar clinical and pathological features. Ts65Dn mice are widely used and serve as the best-characterized animal model of DS. We undertook studies to characterize age-related changes for AD-relevant markers linked to Aβ, Tau, and phospho-Tau, axonal structure, inflammation, and behavior. We found age-related changes in both Ts65Dn and 2N mice. Relative to 2N mice, Ts65Dn mice showed consistent increases in Aβ40, insoluble phospho-Tau, and neurofilament light protein. These changes were correlated with deficits in learning and memory.