AUTHOR=Li Jing , Yu Xiaocheng , Zou Yan , Leng Yangming , Yang Fan , Liu Bo , Fan Wenliang 

TITLE=Altered static and dynamic intrinsic brain activity in unilateral sudden sensorineural hearing loss

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 17 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1257729

DOI=10.3389/fnins.2023.1257729

ISSN=1662-453X

ABSTRACT=Sudden sensorineural hearing loss (SSHL) is an otologic emergency that exhibits alterations in both brain cortical and subcortical structures, as well as changes in brain functional activities involving multiple networks. However, little is known regarding cerebral intrinsic brain activity in SSHL. The aimed of this study is to investigate intrinsic brain activity alterations in SSHL using static and dynamic fractional amplitude of low-frequency fluctuation (fALFF) analysis. Resting-state fMRI data from SSHL patients (unilateral, n=102) and healthy controls (n=73) were acquired and analyzed using static and dynamic fALFF methods. The results revealed significant differences in static fALFF patterns, with SSHL patients exhibiting decreased fALFF in the left fusiform gyrus, left precentral gyrus, and right inferior frontal gyrus, as well as increased fALFF in the left inferior frontal gyrus, left superior frontal gyrus, and right middle temporal gyrus. Dynamic fALFF analysis demonstrated increased fALFF in the right superior frontal gyrus and right middle frontal gyrus in SSHL patients.Moreover, a positive correlation was observed between static fALFF in the left fusiform gyrus and the duration of hearing loss. These findings suggest disrupted intrinsic brain activity and temporal dynamics in SSHL, providing insights into the functional reorganization and potential compensatory mechanisms associated with hearing loss.Understanding these alterations may contribute to the development of targeted interventions and rehabilitation strategies for SSHL management.