AUTHOR=Shi Jiatian , Zhang Xinyue , Chen Jianhua , Shen Ruishi , Cui Huashun , Wu Huangan 

TITLE=Acupuncture and moxibustion therapy for cognitive impairment: the microbiome–gut–brain axis and its role

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 17 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1275860

DOI=10.3389/fnins.2023.1275860

ISSN=1662-453X

ABSTRACT=Cognitive impairment poses a significant burden on individuals, families, and society worldwide. Despite the lack of effective treatment strategies, emerging evidence suggests that the microbiome-gut-brain (MGB) axis may play a critical role in the pathogenesis of cognitive impairment. While targeted treatment is not yet comprehensive, recently acupuncturemoxibustion therapy participate increasingly in treatment of degenerative diseases and has achieved a certain therapeutic effect. In this review, the possible mechanisms by which acupuncture and moxibustion therapy may improve cognitive impairment through the MGB axis are reviewed, including regulating gut microbial homeostasis, improving intestinal inflammation mediated by the neuro-endocrine-immune system, as well as enhancing intestinal barrier function. We also discuss common acupoints and corresponding mechanism analysis to provide insight into further exploration of mechanisms that target the MGB axis and thereby intervene in cognitive impairment.