AUTHOR=Zheng Qingcong , Wang Du , Lin Rongjie , Chen Yuchao , Huang Haoen , Xu Zixing , Zheng Chunfu , Xu Weihong 

TITLE=Mendelian randomization analysis suggests no associations of human herpes viruses with amyotrophic lateral sclerosis

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 17 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1299122

DOI=10.3389/fnins.2023.1299122

ISSN=1662-453X

ABSTRACT=The causal relationship between infections with human herpes viruses (HHVs) and amyotrophic lateral sclerosis (ALS) has been disputed. This study investigated the association between herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), HHV-6, and HHV-7 infections and ALS through a bidirectional Mendelian randomization (MR) method. The genome-wide association studies (GWAS) database were analyzed by inverse variance weighted (IVW), MR-Egger, weighted median, simple mode, and weighted mode methods. MR-Egger intercept test, MR-PRESSO test, Cochran's Q test, funnelWhether there is an association between human herpes viruses (HHVs) infection and amyotrophic lateral sclerosis (ALS) has been controversial, and even little is known about the cause-and-effect relationship.