AUTHOR=Persson Sanna , Moreno Rodrigo 

TITLE=Bounding tractogram redundancy

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 18 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1403804

DOI=10.3389/fnins.2024.1403804

ISSN=1662-453X

ABSTRACT=In tractography, redundancy poses a significant challenge, often resulting in tractograms that include anatomically implausible streamlines or those that fail to represent the brain's white matter architecture accurately. While current filtering methods aim to refine tractograms by addressing these issues, they lack a unified measure of redundancy and can be computationally demanding.We propose a novel framework to quantify tractogram redundancy based on filtering tractogram subsets without endorsing a specific filtering algorithm. Our approach defines redundancy based on the anatomical plausibility and diffusion signal representation of streamlines, establishing both lower and upper bounds for the number of false-positive streamlines and the tractogram redundancy. We apply this framework to tractograms from the Human Connectome Project, using geometrical plausibility and statistical methods informed by the streamline attributes and ensemble consensus. This work advances the understanding of tractogram redundancy and supports the refinement of tractography methods. Future efforts will focus on further validating the proposed framework and exploring tractogram compression possibilities.