AUTHOR=Luo Chun , Zhang FengQi , Shen Danqian , Sun Jing , Zhang YuShan , Xie ZhiJun , Yu XiaLi 

TITLE=Nighttime sleep duration and the prevalence of hyperuricemia: a systematic review and network meta-analysis

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 19 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1436116

DOI=10.3389/fnins.2025.1436116

ISSN=1662-453X

ABSTRACT=ObjectiveAccording to clinical observation and recent studies, there is a significant association between night sleep duration and hyperuricemia. In this study, systematic review and network meta-analysis were performed to evaluate the risk of hyperuricemia associated with different nighttime sleep durations.MethodsSeven databases were searched from database inception to March 2020. Two reviewers independently performed study selection, quality appraisal, and data extraction. Conventional meta-analysis was conducted using either a fixed-effects or random-effects model according to statistical heterogeneity. A Bayesian network meta-analysis was conducted using the consistency model.ResultsSix studies with 416,684 patients and involving different nighttime sleep durations were included. The network meta-analysis showed that compared with normal nighttime sleep duration, the pooled risk ratio (RR) for short nighttime sleep duration was 1.26 (95% confidence interval [CI] 1.22–1.30, p < 0.00001). Compared with long nighttime sleep duration, pooled RR of HUA with normal nighttime sleep duration was 0.81 (95% CI 0.67–0.99, p = 0.03). Compared with long nighttime sleep duration, pooled RR of HUA with short nighttime sleep duration was 1.07 (95% CI 0.90–1.28, p = 0.43).ConclusionThe evidence in this network meta-analysis illustrates that both short and long sleep duration increased the risk of hyperuricemia, and short sleep duration was more harmful. Further high-quality studies are required to explore the Mechanism of the nighttime sleep duration influencing hyperuricemia.Systematic review registrationhttps://www.crd.york.ac.uk/, CRD42024519628.