AUTHOR=Feng Xuyang , Zhang Wenyu , Liu Xiaoxi , Wang Qiuxuan , Dang Xiao , Han Jingxian , Zhang Xuezhu 

TITLE=Ferroptosis-associated signaling pathways and therapeutic approaches in depression

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 19 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1559597

DOI=10.3389/fnins.2025.1559597

ISSN=1662-453X

ABSTRACT=Ferroptosis, a newly identified form of cell death, is characterized by excessive iron accumulation and lipid peroxidation. Studies indicate a strong association between ferroptosis and depression; however, the precise signaling pathways and underlying molecular mechanisms remain unclear. This review summarizes the role of ferroptosis in depression and its associated signaling pathways. Additionally, therapeutic approaches for depression based on ferroptosis theory are reviewed, providing novel targets for the prevention and treatment of depression and laying a foundation for future research on the relationship between ferroptosis and depression.