AUTHOR=Madden Derek , Stephens Tressie M. , Scott Jim , O’Neal Swann Christen , Prather Kiana , Hoffmeister Jordan , Ding Lei , Dunn Ian F. , Conner Andrew K. , Yuan Han 

TITLE=Functional connectivity of default mode network in non-hospitalized patients with post-COVID cognitive complaints

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 19 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1576393

DOI=10.3389/fnins.2025.1576393

ISSN=1662-453X

ABSTRACT=IntroductionNeurologic impairment is common in patients with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. While patients with severe COVID have a higher prevalence of neurologic symptoms, as many as one in five patients with mild COVID may also be affected, exhibiting impaired memory as well as other cognitive dysfunctions.MethodsTo characterize the effect of COVID on the brain, the current study recruited a group of adults with post-COVID cognitive complaints but with mild, non-hospitalized cases. They were then evaluated through formal neuropsychological testing and underwent functional MRI of the brain. The participants in our study performed nearly as expected for cognitively intact individuals. Additionally, we characterized the functional connectivity of the default mode network (DMN), which is known for cognitive functions including memory as well as the attention functions involved in normal aging and degenerative diseases.ResultsAlong with the retention of functional connectivity in the DMN, our results found the DMN to be associated with neurocognitive performance through region-of-interest and whole-brain analyses. The connectivity between key nodes of the DMN was positively correlated with cognitive scores (r = 0.51, p = 0.02), with higher performers exhibiting higher DMN connectivity.DiscussionOur findings provide neuroimaging evidence of the functional connectivity of brain networks among individuals experiencing cognitive deficits beyond the recovery of mild COVID. These imaging outcomes indicate expected functional trends in the brain, furthering understanding and guidance of the DMN and neurocognitive deficits in patients recovering from COVID.