AUTHOR=Ge Lei , Xu Weihua , Liu Wencong , Cui Panpan , Zhang Lei , Ju Hui 

TITLE=Analysis of the correlation between serum vitamin D and hypothalamic-pituitary-adrenal axis hormone levels in patients with post-traumatic stress disorder

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 19 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1622978

DOI=10.3389/fnins.2025.1622978

ISSN=1662-453X

ABSTRACT=ObjectivePost-Traumatic Stress Disorder (PTSD) is a psychological disorder triggered by extreme traumatic events. It is characterized by impaired cognitive function and neuroendocrine dysfunction, particularly dysregulation of the hypothalamic-pituitary-adrenal axis. In recent years, the role of vitamin D in neuroprotection and cognitive function has garnered increasing interest; however, its relationship with hypothalamic–pituitary–adrenal (HPA) axis hormone levels in patients with post-traumatic stress disorder (PTSD) remains poorly understood.MethodsThis study aimed to investigate the correlation between serum vitamin D levels and HPA axis hormones in patients with PTSD. A total of 96 patients with severe trauma admitted to Rizhao People’s Hospital between March 2022 and December 2024 were enrolled and categorized into PTSD and non-PTSD groups according to diagnostic criteria. PTSD symptoms were evaluated using the PTSD Checklist–Civilian Version. Serum levels of 25-hydroxyvitamin D, corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol were measured. Spearman’s correlation analysis and receiver operating characteristic curves were employed to assess associations between vitamin D, HPA axis biomarkers, and PCL-C Scores.ResultsThe results showed that serum 25-hydroxyvitamin D levels were significantly lower in the PTSD group compared to the non-PTSD group (P < 0.001), while CRH and ACTH levels were significantly higher, and cortisol levels were significantly lower (P < 0.001). Spearman correlation analysis indicated that vitamin D levels were negatively correlated with CRH and ACTH levels and positively correlated with cortisol levels (P < 0.05). ROC curve analysis revealed that serum 25-hydroxyvitamin D levels have diagnostic potential for PTSD, with a cutoff value of 16.32 ng/mL, an AUC of 0.698, sensitivity of 86.2%, and specificity of 51.1%.ConclusionThis study demonstrated a correlation between serum vitamin D levels and HPA axis hormone levels in patients with PTSD, suggesting that vitamin D deficiency may be associated with HPA axis dysregulation in PTSD. These findings underscore a potential link between vitamin D deficiency and PTSD, warranting further investigation into the role of vitamin D in the disorder’s pathophysiology and its potential as a therapeutically modifiable factor.