AUTHOR=Li Qiunan , Yu Hao , Zhang Manli , Yuan Xiaotong , Cai Lixin , Kang Guixia 

TITLE=LEM-UNet: an edge-guided network for 3D multimodal images segmentation in focal cortical dysplasia

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 19 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1634606

DOI=10.3389/fnins.2025.1634606

ISSN=1662-453X

ABSTRACT=IntroductionFocal cortical dysplasia (FCD) is one of the common causes of refractory epilepsy. The subtle and indistinct edge of FCD lesions pose considerable challenges for accurate lesion localization. Therefore, we propose an edge guided segmentation network based on Laplacian pyramid to improve the localization performance of FCD lesions.MethodsThis is a retrospective study evaluated on two independent datasets. The proposed Laplacian Edge Mix UNet (LEM-UNet) builds upon the MedNeXt baseline and incorporates the Laplacian Edge Attention (LEA) block and the Multi-strategy Feature Fusion (MFF) block. LEA block captures lesion details and edge information during the encoding phase by integrating Laplacian pyramid feature maps with an attention mechanism, while MFF block fuses edge features with high level features during the decoding phase.ResultsThe model's performance was assessed through 5-fold cross-validation across both Open and Private Datasets, demonstrating superior performance. The average Dice Coefficient achieved 0.452 and 0.597 on the Open and Private Datasets, respectively, representing improvements of 2.40% and 2.90% compared to the baseline model.DiscussionThe results demonstrate the importance of focusing on lesion edge in the FCD segmentation task. The integration of the Laplacian pyramid enhances the mode's ability to capture lesions with blurred edge and subtle features. LEM-UNet exhibits significant advantages over current FCD segmentation algorithms. The source code and pre trained model weights are available at https://github.com/simplify403/LEM-UNet.