AUTHOR=Liu Feifan , Hong Jiayi , Chen Yuhan , Liu Huan , Wang Yue , Su Lijian , Hu Sheng , Fu Jingjing 

TITLE=Development and validation of a CT-based multi-omics nomogram for predicting hospital discharge outcomes following mechanical thrombectomy

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 19 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1643014

DOI=10.3389/fnins.2025.1643014

ISSN=1662-453X

ABSTRACT=ObjectiveThis study aimed to develop a multi-omics nomogram that combines clinical parameters, radiomics, and deep transfer learning (DTL) features of hyperattenuated imaging markers (HIM) from computed tomography scans immediately following mechanical thrombectomy (MT) to predict functional outcomes at discharge.MethodsThis study enrolled 246 patients with HIM who underwent MT. Patients were randomly assigned to a training cohort (n = 197, 80%) and a validation cohort (n = 49, 20%), with an additional internal prospective test cohort (n = 57). A total of 1,834 radiomics features and 25,088 DTL features were extracted from HIM images. Feature selection was conducted using analysis of variance (ANOVA), Pearson’s correlation, principal component analysis (PCA), and least absolute shrinkage and selection operator (LASSO) regression. A support vector machine (SVM)-based nomogram integrating clinical, radiomics, and DTL features was developed to predict functional outcomes at discharge. Its performance was evaluated based on accuracy, sensitivity, specificity, receiver operating characteristic (ROC) curve and area under the curve (AUC) analysis, decision curve analysis (DCA), and the DeLong test.ResultsThe nomogram achieved AUCs of 0.995 (95% CI: 0.989–1.000) in training, 0.959 (95% CI: 0.910–1.000) in validation, and 0.894 (95% CI: 0.807–0.981) in test cohorts. Our nomogram significantly outperformed clinical, radiomics, and DTL models, as well as physician assessments (senior physicians: 0.693, p = 0.001; junior physicians: 0.600, p < 0.001).ConclusionThis multi-omics nomogram, integrating HIM-derived, clinical, radiomic, and DTL features, accurately predicts post-MT discharge outcomes, enabling early identification of high-risk patients and optimizing management to improve prognosis.