AUTHOR=Mpanya Dineo , Sathekge Mike , Klug Eric , Damelin Jenna , More Stuart , Hadebe Bawinile , Vorster Mariza , Tsabedze Nqoba 

TITLE=Gallium-68 fibroblast activation protein inhibitor positron emission tomography in cardiovascular disease

JOURNAL=Frontiers in Nuclear Medicine

VOLUME=Volume 3 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/nuclear-medicine/articles/10.3389/fnume.2023.1224905

DOI=10.3389/fnume.2023.1224905

ISSN=2673-8880

ABSTRACT=Gallium-68 fibroblast activatingactivation protein inhibitor ([ 68 Ga]Ga-FAPI) is a new radiopharmaceutical positioning itself as the preferred agent in patients with malignant tumours, competing with 2-Deoxy-2-[18F]fluoro-d-glucose (2-[ 18 F]FDG) using positron emission tomography (PET). While imaging oncology patients with [ 68 Ga]Ga-FAPI PET, incidental uptake of [ 68 Ga]Ga-FAPI has been detected in the myocardium. This review summarises original research studies associating the visualisation of FAPI-based tracers in the myocardium with underlying active cardiovascular disease.