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CASE REPORT article
Front. Nucl. Med.
Sec. PET and SPECT
Volume 4 - 2024 |
doi: 10.3389/fnume.2024.1451848
Positive Pitfalls of PSMA PET/CT Case Report: Positive Pitfalls of PSMA PET/CT: Diagnostic challenges in Degenerative Bone Lesions including MODIC type 1
Provisionally accepted- American University of Beirut, Beirut, Lebanon
Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is an imaging technique that has demonstrated high sensitivity and specificity in detecting prostate cancer and its metastasis, especially in the bones. This case describes a 60-year-old man who presented for increased prostate-specific antigen (PSA) level and underwent [ 68 Ga]gallium-PSMA-11 PET/CT imaging for better disease assessment. 68 Ga-PSMA-11 PET/CT revealed numerous radiotracer-positive lesions in both prostate lobes with associated sclerotic lesions on L4 and L5, but only L5 showed increased radiotracer avidity raising the possibility of metastasis. Magnetic Resonance Imaging (MRI) raises the possibility of aggressive MODIC type 1 lesion versus infectious/inflammatory process. A biopsy of the radiotracer avid area was performed and showed no evidence of metastasis.The final diagnosis was aggressive MODIC type 1, in keeping with the false positive result of 68 Ga-PSMA-11 PET/CT.
Keywords: PSMA, PET/CT, prostate cancer, Bone lesion, Modic type 1, case report
Received: 19 Jun 2024; Accepted: 17 Jul 2024.
Copyright: © 2024 Moukaddam, El Saheb, Omran, El Ghawi, Abi Ghanem and Haidar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mohamad B. Haidar, American University of Beirut, Beirut, Lebanon
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Hicham Moukaddam