AUTHOR=Dambrain Abel , Boursot Charles , Cohen Tannugi Kévin , Reichart Julien , Lacoeuille Franck 

TITLE=Case Report: Utility of brain [18F]FDG PET/CT in the diagnosis of Sydenham's chorea

JOURNAL=Frontiers in Nuclear Medicine

VOLUME=Volume 4 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/nuclear-medicine/articles/10.3389/fnume.2024.1527150

DOI=10.3389/fnume.2024.1527150

ISSN=2673-8880

ABSTRACT=Sydenham's chorea is an autoimmune reaction against cerebral basal ganglia associated with rheumatic fever, caused by group A beta-hemolytic streptococcus infection. Diagnosis of this condition is difficult because of significant delay between infection onset and symptoms presentation, resulting in few positive biological tests or imaging exams. We report the case of a nine-year-old boy exhibiting hemicorporal abnormal movements with tics for whom [18F]FDG PET/CT exam allowed to make the diagnosis, associated with anti-DNase B elevation. Other biology, spinal tap, EEG and imaging modality like MRI or scanner, were non-contributory.