AUTHOR=Khawaja Owais , Singh Hemindermeet , Luni Faraz , Kabour Ameer , Ali Syed S. , Taleb Mohammed , Ahmed Hafeezuddin , Gaziano John Michael , Djoussé Luc 

TITLE=Egg Consumption and Incidence of Heart Failure: A Meta-Analysis of Prospective Cohort Studies

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 4 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2017.00010

DOI=10.3389/fnut.2017.00010

ISSN=2296-861X

ABSTRACT=Introduction: 
Heart failure (HF) remains a major health problem affecting 5.7 million adults in USA. Data on the association of egg consumption with incident HF have been inconsistent. We therefore conducted this meta-analysis of prospective cohort studies to assess the relation of egg consumption with incident HF in the general population.
Methods: 
Using extensive online search, we conducted a meta-analysis of new onset heart failure following exposure to egg consumption. A random-effect model was used and between studies heterogeneity was estimated with I2. Publication bias was assessed graphically using a funnel plot. All analyses were performed with Comprehensive Meta-Analysis (version 2.2.064).
Results: 
We identified 4 prospective cohorts for a total of 105,999 subjects and 5,059 cases of new onset HF. When comparing the highest (>1/day) to the lowest category of egg consumption, pooled relative risk (RR) of HF was 1.25 (95% CI = 1.12-1.39; p= 0.00). There was no evidence for heterogeneity (I2=0%) nor publication bias. On sensitivity analysis stratification by gender differences, follow up duration, and region where study was conducted did not alter the main conclusion. 
Conclusions: 
Our meta-analysis suggests an elevated risk of incident HF with frequent egg consumption.