AUTHOR=Chen Lijuan , Wu Xiaoli , Qin Haiyan , Zhu Hongchao 

TITLE=The PCT to Albumin Ratio Predicts Mortality in Patients With Acute Kidney Injury Caused by Abdominal Infection-Evoked Sepsis

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.584461

DOI=10.3389/fnut.2021.584461

ISSN=2296-861X

ABSTRACT=Purpose: Considerable evidence suggest that inflammation and malnutrition are common in acute kidney injury (AKI) patients and correlated with mortality of various diseases. Whereas, few studies reported the underlying predictive effects of inflammatory and nutritional markers in combination on the mortality of AKI patients. Herein, we aimed to explore the values of PCT and CRP, as well as ratios of PCT/Alb and CRP/Alb in the poor prognosis of patients with AKI caused by abdominal infection-evoked sepsis.
Patients and methods: The 171 patients with AKI caused by abdominal infection-evoked sepsis were retrospectively studied and divided into survival group (107 cases) and non-survival group (64 cases). Univariate analysis was used to compare the clinical data of the two groups. Multivariate logistic regression analysis was used to analyze the independent risk factors of poor prognosis in patients with sepsis-induced AKI. The ROC curve was used to evaluate the diagnostic value of PCT, CRP, PCT/Alb, and CRP/Alb in the poor prognosis of patients with sepsis-induced AKI.
Results: Univariate analysis revealed that the values of PCT, CRP, CRP/Alb and PCT/Alb were significantly different between AKI survival and non-survival groups, and further analysis found that PCT and PCT/Alb were independent risk factors for poor prognosis in patients with sepsis-induced AKI adjusting by age and gender. Of note, the predictive accuracy (0.864 vs. 0.807), specificity (85.2 vs. 82.5) and sensitivity (75.1 vs. 66.9) of PCT/Alb were all higher than the simple PCT.
Conclusions: The ratio of PCT to Alb is an independent risk factor with better robust risk assessment for the poor prognosis of patients with sepsis-induced AKI, and offers the potential to improve the management and lower the mortality of this type of disease.