AUTHOR=Prince Md. Raihan Uzzaman , Zihad S. M. Neamul Kabir , Ghosh Puja , Sifat Nazifa , Rouf Razina , Al Shajib Gazi Mohammad , Alam Md. Ashraful , Shilpi Jamil A. , Uddin Shaikh J. 

TITLE=Amaranthus spinosus Attenuated Obesity-Induced Metabolic Disorders in High-Carbohydrate-High-Fat Diet-Fed Obese Rats

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.653918

DOI=10.3389/fnut.2021.653918

ISSN=2296-861X

ABSTRACT=Amaranthus spinosus is a common vegetable of Bangladesh and well-known for its ethnomedicinal uses. In this study, we have evaluated the ability of powdered supplementation, methanol extract and aqueous extract of A. spinosus in attenuating in high-carbohydrate-high-fat (HCHF) diet induced obesity and associated metabolic disorders in female obese rates. A number of parameters have been analyzed in this study including body weight, organ weight, fat deposition, glycemic status, lipid levels, hepatic and renal biomarkers, hepatic antioxidant status and hepatosteatosis. All three samples of A. spinosus significantly reduced weight gain, organ weight and abdominal fat deposition. Improved glucose tolerance and lipid parameters were seen in obese rats administered with A. spinosus powder, methanol extract and aqueous extract. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and creatine kinase levels were normalized by the test samples. A. spinosus boosted hepatic antioxidant levels including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Histopathology of liver tissue revealed increased fat infiltration and higher steatosis score in HCHF diet fed obese rats which was brought down by A. spinosus. Analyzing all the results it can be concluded that this medicinal herb is beneficial in the management of obesity and obesity induced metabolic disorders making it a prospective food supplement.