AUTHOR=Wang Xiao-Bin , Wu Qi-Jun , Liu Fang-Hua , Zhang Shuang , Wang Han-Yuan , Guo Ren-Hao , Leng Xu , Du Qiang , Zhao Yu-Hong , Pan Bo-Chen 

TITLE=The Association Between Dairy Product Consumption and Asthenozoospermia Risk: A Hospital-Based Case-Control Study

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.714291

DOI=10.3389/fnut.2021.714291

ISSN=2296-861X

ABSTRACT=Background
Evidence of an association between dairy product and related nutrient intake, and the asthenozoospermia risk have been limited and controversial.
Methods
A case-control study including 549 men with asthenozoospermia and 581 healthy controls interviewed in the infertility clinics of Shengjing Hospital of China Medical University between June, 2020 and December, 2020. Dietary intake was assessed with a validated food frequency questionnaire, and semen parameters were analyzed according to the World Health Organization guidelines. The daily intake of dairy products and related nutrients was categorized into three groups, and the lowest tertile was used as the reference category. An unconditional multiple logistic regression was used to estimate the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for asthenozoospermia risk.
Results
After adjustment for potential confounders, we found no statistically significant associations between the intake of total dairy and asthenozoospermia risk (ORT3vs.T1=1.14, 95%CI=0.80–1.58). Additionally, we generated null findings regarding the main related nutrients from dairy, including protein (ORT3vs.T1=1.14, 95%CI=0.82–1.59), fat (ORT3vs.T1=1.23, 95%CI=0.88–1.71) and calcium (ORT3vs.T1=1.15, 95%CI=0.83–1.60), and asthenozoospermia risk. Of note, after stratification by body mass index (BMI), and the fat consumption from dairy was significantly associated with a higher asthenozoospermia risk (ORT3vs.T1=1.77, 95%CI=1.03–3.06) among participants with a BMI below 25 kg/m2.
Conclusion
This study provided limited evidence of an association between the intake of total dairy, protein, fat, and calcium, and the asthenozoospermia risk. Further studies are warranted to confirm our findings in the future.