AUTHOR=Rastgoo Samira , Ebrahimi-Daryani Nasser , Agah Shahram , Karimi Sara , Taher Mohammad , Rashidkhani Bahram , Hejazi Ehsan , Mohseni Fatemeh , Ahmadzadeh Mina , Sadeghi Amir , Hekmatdoost Azita 

TITLE=Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in Irritable Bowel Syndrome Management

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 8 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.746703

DOI=10.3389/fnut.2021.746703

ISSN=2296-861X

ABSTRACT=Background & Aims: Although irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders presenting to gastroenterologists, therapeutic strategies have not yet well established. Accordingly, we conducted a randomized, double-blind, placebo controlled, clinical trial to evaluate the possible superiority adding glutamine supplement to low fermentable oligo- di- mono- saccharides and polyols (FODMAP) diet in patients with IBS. 
Methods: Eligible adults were randomized to receive low FODMAP diet either with glutamine (15 gram/day) or placebo for 6 weeks. The primary end point was a significant reduction in IBS Severity Scoring System (IBS-SSS). Secondary end points were changes in IBS symptoms and quality of life. 
Results: Fifty patients were enrolled in the study, while 22 participants completed the study protocol in each group. The glutamine group had significant changes in total IBS-severity score, dissatisfaction of bowel habit and interference with community function (58% reduction; P<0.001, 57% reduction; P <0.001, 51% reduction; P=.043, respectively). Improvement in IBS-severity score of more than 45% was observed in 22 of 25 participants (88%) in glutamine group, while it was only in 15 of 25 participants (60%) in control group (P=0.015). 
Conclusions: Our findings indicate the superiority of adding glutamine supplementation to low FODMAP diet in amelioration of IBS symptoms, while confirming the beneficial effects of low FODMAP diet in IBS management.