AUTHOR=Ruan Guo-Tian , Ge Yi-Zhong , Xie Hai-Lun , Hu Chun-Lei , Zhang Qi , Zhang Xi , Tang Meng , Song Meng-Meng , Zhang Xiao-Wei , Liu Tong , Li Xiang-Rui , Zhang Kang-Ping , Yang Ming , Li Qin-Qin , Chen Yong-Bing , Yu Kai-Ying , Braga Marco , Cong Ming-Hua , Wang Kun-Hua , Barazzoni Rocco , Shi Han-Ping 

TITLE=Association Between Systemic Inflammation and Malnutrition With Survival in Patients With Cancer Sarcopenia—A Prospective Multicenter Study

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 8 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.811288

DOI=10.3389/fnut.2021.811288

ISSN=2296-861X

ABSTRACT=Objective: Systemic inflammation and malnutrition are correlated with cancer sarcopenia and have deleterious effects on oncological outcomes. However, the combined effect of inflammation and malnutrition in patients with cancer sarcopenia remains unclear. 
Methods: We retrospectively collected information on 1204 patients diagnosed with cancer sarcopenia and selected the optimal inflammation marker and performed the survival analyses and combined analysis. 
Results: Among the 1204 patients, the mean (SD) age was 64.5 (11.4%) and 705 (58.60%) were male. The best indicator of inflammation we selected was advanced lung cancer inflammation index (ALI) in patients with cancer sarcopenia. The patients were categorized into the high ALI group (≥18.39) and the low ALI group (<18.39) according to the optimal survival cut-off curve. The prognosis for patients in the low ALI group was worse than that of patients in the high ALI group (HR [95%CI] = 1.666 [1.347-2.060], P<0.001). Patients with both low ALI and severe malnutrition (vs. patients with high ALI and well-nourished) had nearly 3-fold death risk (P<0.001). 
Conclusions: The inflammation indicator of ALI was better than NLR, PNI, SII, and PLR in patients with cancer sarcopenia. Inflammation combined with severe malnutrition has a nearly 3-fold death risk in patients with cancer sarcopenia.