AUTHOR=Akter Saleha , Addepalli Rama , Netzel Michael , Tinggi Ujang , Fletcher Mary , Sultanbawa Yasmina , Osborne Simone 

TITLE=In vitro Bioaccessibility and Intestinal Absorption of Selected Bioactive Compounds in Terminalia ferdinandiana

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 8 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.818195

DOI=10.3389/fnut.2021.818195

ISSN=2296-861X

ABSTRACT=Terminalia ferdinandiana (or Kakadu plum), a native Australian fruit with potential health benefits, contains bioactive compounds like ellagic acid, ascorbic acid, and calcium, and antinutrients like oxalic acid. However, little is known about the biological fate of these compounds following ingestion, therefore the aim of this study was to evaluate in vitro bioaccessibility and intestinal absorption of T. ferdinandiana compounds using the Infogest static digestion model, and Caco-2-HT29-MTX-E12 intestinal absorption model. No significant changes (P > 0.05) were observed in total ascorbic acid content throughout in vitro digestion, while bioaccessibility of ellagic acid, oxalic acid, and calcium increased significantly from 33%, 72%, and 67% in the gastric phase, to 48%, 98%, and 90% in the intestinal phase, respectively. The intestinal absorption study revealed variable rates of movement across the cell barrier. Findings reveal novel and important insights for prediction of in vivo bioavailability of selected T. ferdinandiana compounds.