AUTHOR=Gou Ruoyu , Gou Yufan , Qin Jian , Luo Tingyu , Gou Qiannan , He Kailian , Xiao Song , Li Ruiying , Li Tingjun , Xiao Jie , Chen Ziqi , Chen Yulu , Li You , Zhang Zhiyong 

TITLE=Association of dietary intake of saturated fatty acids with hypertension: 1999–2018 National Health and Nutrition Examination Survey

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1006247

DOI=10.3389/fnut.2022.1006247

ISSN=2296-861X

ABSTRACT=OBJECTIVE: This study aimed to assess the relationship between dietary intake of saturated fatty acid (SFA) and its subtypes (C4:0, C6:0, C8:0, C10:0, C12:0, C14:0, C16:0, C18:0) and hypertension.
DESIGN, PARTICIPANTS, AND METHODS: Adults aged 20 years and older based used the U.S. Health and Nutrition Survey (1999–2018) were used as participants. Two averages of 24 h dietary recall data were obtained for weight-adjusted continuous cross-sectional analysis. A logistic regression model was used to estimate the weighted dominance ratio and its 95% confidence interval for hypertension.
RESULTS: Of the 26,778 respondents aged 20 years and older, hypertensive patients had a hypertension prevalence of 35.06% and less (mean ± SD) dietary intake of SFA, C14:0, and C16:0 compared with normal subjects (P<0.0001). After adjusting for confounders, the second quartile of C12:0 (0.80 [0.66-0.96]) may be a protective factor for hypertension among respondents, and the third quartile of C12:0 (0.72 [0.56-0.93]) may be a protective factor for hypertension in men. In addition, an interaction was observed among C12:0, age, and hypertension, indicating that women consuming C16:0 dose at the second quartile (0.75 [0.56-1.00]) may be a protective factor for hypertension. An interaction was also observed between middle-aged respondents (45–64 years) and SFA on hypertension.