AUTHOR=Fatahi Somaye , Alyahyawi Naseem , Albadawi Naryman , Mardali Farzaneh , Dara Naghi , Sohouli Mohammad Hassan , Prabahar Kousalya , Rohani Pejman , Koushki Nazanin , Sayyari Aliakbar , Hosseini Amir Hossein , Abu-Zaid Ahmed 

TITLE=The association between vitamin D status and inflammatory bowel disease among children and adolescents: A systematic review and meta-analysis

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1007725

DOI=10.3389/fnut.2022.1007725

ISSN=2296-861X

ABSTRACT=Aim: Vitamin D deficiency is very common among IBD children. Since there are conflicting results between the association of vitamin D and IBD, we conducted this systematic review to confirm the association of vitamin D with IBD.
Method: We conducted a systematic search in Scopus, Cochrane Library, Web of Science, PubMed, Google scholar to find relevant studies. Articles with cross-sectional and case-control designs which reported the association between vitamin D and IBD among children were included. 
Results: Eventually 9 studies (with 16 effect sizes) reported the mean and SD or median and inter quartile range of serum vitamin D levels in both IBD and control subjects. The random effects meta-analysis revealed that subjects with IBD had -1.159 ng/ml (95% CI:  -2.783, 0.464) lower serum vitamin D concentrations compared with their healthy counterparts, but this difference was not significant. Thirteen studies (with 18 effect sizes) including a total of 2602 participants provided information for prevalence of vitamin D deficiency or insufficiency in IBD patients as 44% (95% CI: 0.34 - 0.54) with significant heterogeneity noted among studies (p<0.001; I2=97.31%).
Conclusions: This systematic and meta-analysis study revealed that vitamin D deficiency was associated with IBD. Longitudinal studies should be conducted in future to confirm our findings. Large randomized controlled trials assessing the doses of supplementation of vitamin D would provide better understanding of the association between vitamin D and IBD.