AUTHOR=Zhao Jiuxiang , Zou Hong , Huo Yanling , Wei Xiaoyi , Li Yu 

TITLE=Emerging roles of selenium on metabolism and type 2 diabetes

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1027629

DOI=10.3389/fnut.2022.1027629

ISSN=2296-861X

ABSTRACT=Selenium is recognized as an essential element for human health and enters human body mainly via diet. Selenium is key constituent in selenoproteins, which exert essential biological functions, including anti-inflammatory and antioxidant effects. As type 2 diabetes, insulin resistance, β-cell dysfunction, and impaired glucose tolerance are all reported to associate with oxidative stress, selenium is expected to protect against type 2 diabetes based on the antioxidant and anti-inflammatory properties of several selenoproteins. The mechanism between selenium and type 2 diabetes remains complex, despite of the clear link between certain selenoproteins with glucose metabolism or insulin resistance. According to research, several selenoproteins participate in type 2 diabetes regulation, including glutathione peroxidase, selenoprotien P and selenoprotein S. To better understand the relationship between selenoproteins and type 2 diabetes, we summarize the existing mechanism of action. Understanding the association between selenium and type 2 diabetes is important for guiding clinical practice, developing effective public health policies, and ultimately counteracting health issues associated with selenium deficiency.