AUTHOR=Li Xiao-Xiang , Liu Chang , Dong Shu-Ling , Ou Can-Song , Lu Jian-Liang , Ye Jian-Hui , Liang Yue-Rong , Zheng Xin-Qiang 

TITLE=Anticarcinogenic potentials of tea catechins

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1060783

DOI=10.3389/fnut.2022.1060783

ISSN=2296-861X

ABSTRACT=Catechins are a cluster of polyphenolic bioactive components in green tea. Anticarcinogenic ef-fects of tea catechins have been reported since the 1980s, but it has been controversial. The pre-sent paper reviews the advances in studies on the anticarcinogenic activities of tea and catechins, including epidemiological evidence and anticarcinogenic mechanism. Tea catechins showed an-tagonistic effects on many cancers, such as gynecological cancers, digestive tract cancers, incident glioma, liver and gallbladder cancers, lung cancer, etc. The mechanism underlying the anti-carcinogenic effects of catechins involves in inhibiting the proliferation and growth of can-cer cells, scavenging free radicals, suppressing metastasis of cancer cells, improving im-munity, interacting with other anticancer drugs, and regulating signaling pathways. The inconsistent results and their causes are also discussed in this paper.