AUTHOR=Gao Zhiwei , Xie Jianfeng , Li Cong , Liu Ling , Yang Yi 

TITLE=High Dose Vitamin D3 Supplementation Is Not Associated With Lower Mortality in Critically Ill Patients: A Meta-Analysis of Randomized Control Trials

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.762316

DOI=10.3389/fnut.2022.762316

ISSN=2296-861X

ABSTRACT=<sec><title>Background</title><p>Vitamin D deficiency is a common condition in critically ill patients. A high dose of vitamin D3 can rapidly restore vitamin D levels. The aim of this meta-analysis was to synthesize the results from up-to-date randomized control trials (RCT) and validate the effect of vitamin D3 in critically ill patients.</p></sec><sec><title>Study Methods</title><p>Several databases, including PubMed, Web of Science, EMBASE, and the Cochrane Central database, were searched up to December 4th, 2020. All RCTs that investigated the use of a high dose of vitamin D3 in critically ill patients and reported mortality data were included in the meta-analysis. The primary outcome was the mortality truncated to day 28 and day 90.</p></sec><sec><title>Results</title><p>A total of 10 RCTs enrolling 2058 patients were finally included. The use of a high dose of vitamin D3 in critically ill patients could not decrease the mortality truncated to day 28 (RR 0.93, 95% CI 0.78–1.11, <italic>P</italic> = 0.43) or day 90 (RR 0.91, 95% CI 0.79–1.05, <italic>P</italic> = 0.21). A high dose of vitamin D3 could significantly reduce the ventilator days (MD −9.38, 95%CI −13.44 to −5.31, <italic>P</italic> &lt; 0.001), but there were no statistic difference in length of ICU stay (MD −2.76, 95% CI −6.27 to 0.74, <italic>P</italic> = 0.12) and hospital stay (MD −2.42, 95% CI −6.21 to 1.36, <italic>P</italic> = 0.21). No significant difference was observed in adverse events between the vitamin D3 group and the placebo group.</p></sec><sec><title>Conclusion</title><p>The use of high dose vitamin D3 was not associated with decreased mortality in critically ill patients, but could significantly reduce the ventilator days.</p></sec><sec><title>Systematic Review Registration</title><p><ext-link ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/prospero/" xmlns:xlink="http://www.w3.org/1999/xlink">https://www.crd.york.ac.uk/prospero/</ext-link>, identifier: CRD42020179195.</p></sec>