AUTHOR=Wang Xiaomei , Xu Xiaogang , Mao Genxiang , Guo Yue , Wang Guangce , Sun Xue , Xu Nianjun , Zhang Zhongshan 

TITLE=Structural Characterization of Gracilariopsis lemaneiformis Polysaccharide and Its Property in Delaying Cellular Senescence

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.876992

DOI=10.3389/fnut.2022.876992

ISSN=2296-861X

ABSTRACT=Sulfated polysaccharide was isolated from Gracilariopsis lemaneiformis (PGP) and its property in delaying H2O2-induced 2BS cellular senescence was studied. The results showed that PGP was a linear polysaccharide containing alternating α-(1→3)- and β-(1→4)- galactopyranose units. Most of sulfate groups are at C6 of the -(1→4)-α-D-Galp, and a small part of them are at C3 and C6. PGP pretreatment could decrease SA-β-gal positive cells and prevent the formation of SAHF induced by H2O2 in a dose dependent manner. It is speculated that PGP may delay aging by down regulating the expression of p21 and p53 genes. The finding provides new insights into the beneficial role of G. lemaneiformis polysaccharide on retarding senescence process.