AUTHOR=Alcala-Diaz Juan F. , Arenas-de Larriva Antonio P. , Torres-Peña Jose D. , Rodriguez-Cantalejo Fernando , Rangel-Zuñiga Oriol A. , Yubero-Serrano Elena M. , Gutierrez-Mariscal Francisco M. , Cardelo Magdalena P. , Luque Raul M. , Ordovas Jose M. , Perez-Martinez Pablo , Delgado-Lista Javier , Lopez-Miranda Jose 

TITLE=A Gene Variation at the ZPR1 Locus (rs964184) Interacts With the Type of Diet to Modulate Postprandial Triglycerides in Patients With Coronary Artery Disease: From the Coronary Diet Intervention With Olive Oil and Cardiovascular Prevention Study

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.885256

DOI=10.3389/fnut.2022.885256

ISSN=2296-861X

ABSTRACT=Background and aims: rs964184 variant in the ZPR1 gene has been associated with blood lipids levels both in fasting and postprandial state and with the risk of myocardial infarction in high-risk cardiovascular patients. However, whether this association is modulated by diet has not been studied.

Objective: To investigate whether the type of diet (low-fat or Mediterranean diets) interacts with genetic variability at this loci to modulate fasting and postprandial lipids in coronary patients. 

Methods: The genotype of the rs964184 polymorphism was determined in the Cordioprev Study population (NCT00924937). Fasting and Postprandial triglycerides were assessed before and after three years of dietary intervention with either a Mediterranean or a low-fat diet. Postprandial lipid assessment was done by a 4-hour oral fat tolerance test (OFTT). Differences in triglycerides levels were identified using repeated-measures ANCOVA. 

Results: From 523 patients (85% males, mean age 59 years) that completed the OFTT at baseline and after 3 years of intervention and had complete genotype information, 125 of them were carriers of the risk allele G. At the start of the study, these patients showed a higher fasting and postprandial TG plasma levels. After three years of dietary intervention, G-carriers following a Mediterranean Diet maintained higher fasting and postprandial triglycerides, while those on the low-fat diet reduced their postprandial triglycerides to similar values to the population without the G-allele. 

Conclusions: After three years of dietary intervention, the altered postprandial triglyceride response induced by genetic variability in the rs964184 polymorphism of the ZPR1 gene can be modulated by a low-fat diet, better than by a Mediterranean diet, in patients with coronary artery disease.