AUTHOR=You Huimin , Tan Yue , Yu Dawei , Qiu Shuting , Bai Yan , He Jincan , Cao Hua , Che Qishi , Guo Jiao , Su Zhengquan 

TITLE=The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.886902

DOI=10.3389/fnut.2022.886902

ISSN=2296-861X

ABSTRACT=Intestinal environment disorder is a potential pathological mechanism to induce obesity. At present, there is increasing evidence proving that intestinal environment homeostasis disorders can affect various metabolic organs, such as fat and liver, and lead to metabolic diseases. However, there are few therapeutic approaches and methods related to obesity and the intestinal environment. In this paper, on the one hand, we discuss how intestinal microbial metabolites SCFA regulate intestinal function to improve obesity and the possible mechanisms and pathways related to obesity-related pathological processes (depending on SCFA-related receptors such as GPCRs, MCT and SMCT, and through epigenetic processes). On the other hand, dietary management intervention to enrich SCFA-producing bacteria and target specific SCFA-producing bacteria and fecal bacteria transplantation therapy to restore the composition of gut microbiota to regulate SCFA can help prevent or improve obesity. Finally, we believe that it will be of great significance to establish a working model of gut-SCFA-metabolic disease development in the future for the improvement of human health.