AUTHOR=Hu Biao , He Pei-yao , Zhong Nan-nan , Gao Zi-min , Guo Jiang-long , Feng Jun-tao , Huang Chu-qin , Yang Jun-bo , Sun Dong-lin 

TITLE=Blood Lead and High-Density Lipoprotein Concentrations in Relation to Human Blood Pressure: A Cross Sectional Study

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.899780

DOI=10.3389/fnut.2022.899780

ISSN=2296-861X

ABSTRACT=Background: While the relationship between blood pressure and blood lead has been studied more extensively, the effect of high-density lipoprotein (HDL) concentration on this relationship remains uncertain. Therefore, this study aimed to determine the effect of HDL concentration on the relationship between blood lead and blood pressure.
Methods: The research used cross-sectional data fro
m the 2005-2014 National Health and Nutrition Examination Survey (NHANES), which included 16,451 participants aged 20-60 years. Multivariable linear regression was used to evaluate the correlation among blood lead, systolic blood pressure (SBP), and diastolic blood pressure (DBP).  HDL concentration was determined by low HDL concentration (≤49mg/dl) and high HDL concentration (>49mg/dl) stratified. The effect of HDL concentration was assessed by an interaction test between blood lead and SBP in multivariable linear regression.
Results: In this cross-sectional research, we identified a positive correlation between blood lead and SBP, but not DBP. The relationship between blood lead and SBP was different in the group with low and high HDL concentrations (β:0.21 95%Cl: -0.05-0.46 vs β:0.47 95%Cl: 0.15-0.79). In addition, high HDL significantly altered the positive correlation between blood lead and SBP (P-value of interaction < 0.001).
Conclusion: The study suggests an interaction between HDL and blood lead in elevating SBP, which may have important clinical implications.