AUTHOR=Liu Guodong , Zou Chen , Jie Yu , Wang Pei , Wang Xiaoyan , Fan Yu 

TITLE=Predictive Value of Geriatric Nutritional Risk Index in Patients With Lower Extremity Peripheral Artery Disease: A Meta-Analysis

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.903293

DOI=10.3389/fnut.2022.903293

ISSN=2296-861X

ABSTRACT=Background: Conflicting results have been reported on the value of Geriatric Nutritional Risk Index (GNRI) in predicting adverse outcomes in patients with peripheral artery disease (PAD). The objective of this meta-analysis was to evaluate the association of GNRI with adverse outcomes in patients with lower extremity PAD. 
Methods: Relevant studies were comprehensively searched in PubMed and Embase databases until December 31, 2021. Eligible studies should evaluate the value of GNRI in predicting major adverse cardiovascular and leg events (MACLEs), all-cause mortality, and amputation in lower extremity PAD patients. 
Results: Eight studies reporting on 9 articles involving 5541 patients were included. A fixed-effect model meta-analysis showed that PAD patients with low GNRI had an increased risk of MACLEs (adjusted risk ratio [RR] 2.26; 95% confidence interval [CI] 1.54–3.31) and all-cause mortality (RR 2.38; 95% CI 1.71–3.31) compared with those with high GNRI. When analysis of GNRI by continuous data, 10 units GNRI decrease was associated with 36% and 44% higher risk of MACLEs and all-cause mortality, respectively. However, per 10 units GNRI score decrease was not significantly associated with higher risk of amputation (p=0.051).
Conclusion: Low GNRI may an independent predictor of adverse outcomes in patients with lower extremity PAD. Routine screening nutritional status using the GNRI may provide important prognostic information in PAD patients.